Sex, Genes and Chromosomes

Biological sex is central to our continued existence. Yet the mechanism that determines sex, rather than being rational and conserved, is a battlefield of warring genes, sexual antagonism, unbalanced expression and self-destructing sex chromosomes that come in bewildering varieties.Drawing on 50 years of research in three fields in which the author has played key roles, this unique book explores the function, activity and evolution of sex genes and chromosomes in humans and other animals. Providing eye-witness stories of early discoveries and modern genomic insights, it examines how genes and chromosomes determine sex; delving into key breakthroughs, theories on gene and chromosome function, and the enormous scope for variation in body traits and behaviour.Reflecting the huge advances in genetics and genomics that help explain the wonders of human existence and evolution, this book is a fascinating resource for anyone interested in the biology of sex– particularly students and researchers in reproduction, genetics and evolution.

• Features an introductory chapter for non-scientists that simplifies complex biological principles and methodologies
• Uses examples of sex chromosome function, regulation and evolution to illustrate important general principles like genome evolution and epigenetics
• Leavens the high information content with explanations of scientific quirks and first-hand stories of key discoveries, providing a glimpse of the excitement and fun in a career studying sex
• Concludes with a chapter that explores human sex and sexuality through a genetic and evolutionary lens, offering insight into how biological and social factors shape human diversity